MAMMOTH BLOOD GIVES HOPE FOR CLONING

Russian researchers reported last week that they’d discovered a very well preserved mammoth carcass lying under ice and tundra in the Lyakhovsky Islands north of the Arctic Circle. Word of the find, and the fact that flowing blood was recovered from the beast, spread around the popular press like wildfire. “The fragments of muscle tissues, which we’ve found out of the body, have a natural red color of fresh meat,” said expedition leader Semyon Grigoriev in a statement from North-Eastern Federal University (NEFU) in Yaktusk, Siberia. “The blood is very dark, it was found in ice cavities bellow the belly, and when we broke these cavities with a poll pick, the blood came running out.”
Grigoriev noted that the discovery could be just the spark needed for a joint mammoth cloning project between NEFU and the South Korean Sooam Biotech Research Foundation. “It was important to discover the mammoth in cold weather, because the unique discovery would melt in summer or autumn, and the priceless material for joint project ‘Mammoth rebirth’ of NEFU and Sooam foundation could disappear from thawing and wild animals,” he said.
But is the hope of finding viable DNA and possibly even intact cells in the mammoth really that high? Scientific American reached out to some mammoth experts who weren’t involved in the latest discovery, which was announced in the press before publication in the scientific literature, to temper the enthusiasm. “[The Russian team has] not found any ‘living cell’—at most they could hope to find what the cloning enthusiasts might call a cell with ‘viable’ DNA, meaning that it would be intact enough to use in the context of a cloning effort,” wrote Daniel Fisher of the University of Michigan in an email to Scientific American. “In fact, although there is much talk of ‘viability’ of this sort, I think it remains to be demonstrated that any DNA from a mammoth meets this criterion. In general, ancient DNA is highly fragmented and by no means ‘ready to go’ into the next mammoth embryo.”
The University of Manitoba’s Kevin CampbellScientific American that the blood, which is apparently still in a liquid state even at -17° C, very well could contain intact proteins. “Since the sample was collected from outside the body, it is likely that there is also ‘contamination’ from myoglobin and possibly bacteria (for example),” he wrote in an email to the magazine. “Based on the color alone, I think it is pretty safe to say that there is indeed a fair amount of hemoglobin (and possibly myoglobin) in the vials.”

, who has participated in research that successfully reconstructed mammoth hemoglobin using ancient DNA, told
Cambell and Fisher both indicated that the mammoth research community is very interested in this recent discovery and that the newly unearthed carcass will now be studied in great detail to answer some of these intriguing questions.

Drugged Fish Act Different

An anti-anxiety medication that has found its way from water treatment plants into ponds and streams of Europe may alter the behavior of perch even at low concentrations, according to a study published today (February 14) in Science. Fish exposed to the drug, called oxazepam, tended to eat more quickly and were more active and less social than they had been prior to drug exposure and compared with their unexposed peers.
“It’s definitely an interesting study,” said David Skelly, an ecologist at Yale University who was not involved in the research. “It’s joining a group of exposure studies that are showing very clearly that the individual chemicals that are showing up as environmental contaminants are ecologically relevant.”
Previously researchers have raised concerns about all manner of pharmaceuticals in the water, from estrogens suggested to cause reproductive abnormalities in frogs to psychoactive drugs linked to autism in fish. Oxazepam is a type of benzodiazepine, drugs that work by binding to GABA receptors and are used to treat anxiety. Since many animals have these receptors, it stands to reason that benzodiazepines might influence animal behavior, Brodin said, but they “weren’t being studied [in animals] in environmentally relevant quantities.”
Testing effluent from a sewage treatment plant in Sweden and downstream water from the River Fyris, environmental scientist Tomas Brodin of Umeå University and colleagues found 0.58 micrograms of oxazepam per liter in the river and 0.73 micrograms per liter in the treated wastewater—concentrations consistent with previously reported levels of benzodiazepine drugs in other parts of the world.
The researchers then took European perch raised in clean water and put them in water with either a low dose of 1.8 micrograms of oxazepam per liter, or a high dose of 910 micrograms per liter. By the end of the 7-day treatment, the fish on the lower drug dose had accumulated levels of oxazepam in their tissues similar to those found in wild perch in the River Fyris.
Following exposure to the medicated water at either the high or low dose, fish spent more time swimming around their tanks. When the scientists put zooplankton in water, the exposed fish found and ate them more rapidly than the control fish, but showed low interest in other fish. The researchers also found that fish treated with the high dose of the drug scored higher on tests of boldness, or their willingness to explore novel situations.
Bodin suggested that the behavioral changes could have ecological consequences. For instance, hungry, drug-dosed fish might deplete algae-eating plankton, which could in turn cause algal blooms. On the other hand, an asocial, highly active fish might be at increased risk of being eaten.
But Skelly cautioned against going too far predicting ecological effects. “Just because you saw these changes, you can’t say very much about how it’s going to pan out in the field,” he says. In the wild, the very presence of predators might change the fish’s behavior, he noted. Oxazepam might also interact with a cocktail of other drugs that had made it into the water.
Still, Brodin said, the results are an indication of the effects benzodiazepines and many other psychoactive drugs could be having on a whole range of animals. “It’s very probable that these behavioral changes are going on in aquatic species around the world as we speak,” he said.

INSECT SOAK UP THE SUN

Aphids are one of the most unique organisms in the animal kingdom. In addition to being among the most destructive pets, some aphid species are the only animals known to produce carotenoids–light absorbing pigments that form part of the photosynthetic machinery of plants, algae, and certain fungi.
Now, an international group of researchers led by entomologist Alain Robichon from the Sophia Institute in France, have proposed that carotenoid-producing aphids can actually use the pigment in a photosynthetic-like process to produce ATP–the cellular energy molecule.

But whether the insects can use the power of light to ultimately synthesize glucose and other compounds is far from clear, Yale University geneticist Nancy Moran, who was not involved in the study, told Nature. “Energy production seems to be the least of an aphid’s problems–their diet is loaded with excessive sugar, most of which they cannot use,” she said. However, the authors counter that aphids may use the process as an energy back-up during times of stress, Nature reported.

THE HUMAN SPINE

UNDERGROND HELL IN RUSSIA

place or symbolical? Bible talks about hell several times. But I would like to share you this true to life experience of scientist named Dr. Azzacove from Russia who doesnt believe in God, in bible and hell. This news appeared in the well respected Finland newspaper, Ammenusastia.

Heres what happened, a group of geological scientist was drilling a 14.4 kilometers hole deep in Siberia, … then after using their super sensitive microphones to test the underground for sound intervals, they shocked on what they heard. First they heard a high pitched sound, they thought the sound was from their digging devices. After some adjustments: They heard a terrifying screams…, not just screams of a single human, but screams of millions human voice, a screams of pain.

Dr. Azzavoc the project manager of the scientist says. Aside from the screams they heard they were also surprised on a very high temperature around 1,100 degrees celsius. They are afraid to continue the project, and about half of the scientist quit because of fear.
Dr. Azzavoc is a communist, doesnt believe on God, and bible.. But after this event. He believes now that Hell really exist!. If you want to download the hell screaming sounds in mp3 format… click here. You may put that mp3 file in your cellphones, ipods so you can share this to other.

NEW DISCOVERY BY SALAMI TAIWO

1) The tooth is the only part of the human body that cant repair  itself.
2) In an average adult the volume of blood is one eleventh of the body weight, or between 5 and 6 quarts.
3) The feet account for one quarter of all the human bodies bones.That is 52 bones in the feet alone.
4) The first toy balloon,made of vulcanized rubber, was thought of by someone in the J.G Ingram company in          London,England in 1847.
5) A cough releases an explosive charge of air that moves at speeds up to 60 mph.
6) Do not cut or push back your toenail cuticles,Cuticles protect you against bacterial infection.
7) Saturn rings are about 500,000 miles in circumference but only about a foot thick.

WHY WE YAWN

Yawning, which opens the sinuses located to the left and right of the nose, acts to cool the brain when it gets too hot.
Excessive yawning, argue the researchers, appears to be a symptom of conditions that increase the brain or core temperature, such as damage to the central nervous. In addition, fits of yawning often precede epileptic seizures and migraines. Therefore, the authors say, understanding the physiological purpose of the reflex could have medical relevance.
Earlier work by the authors showed that the brains of mice increased in temperature just before a yawn and decreased directly after. The authors propose that the mucus within the sinus constantly evaporates and, like a refrigerator, cools the surrounding blood vessels and cerebrospinal fluid. A yawn, they suggest, would amplify this process by stretching the jaw, which flexes the walls of the sinus bringing new air into it rapidly cooling an overheated brain.

How Blood Cells Thwart Malaria

Two hemoglobin mutations, including one that causes sickle cell anemia, may protect people from severe malaria by gumming up the cellular machinery the parasite uses to transmit deadly proteins to the cell surface. The findings, published today (November 10) in Science Express, suggest potential ways to fight the deadly disease.

“It’s a great study,” said Rick Fairhurst, who studies malaria pathogenesis and immunity at the National Institute of Allergy and Infectious Diseases, and was not involved in the study. “It really takes us a huge, giant leap forward.” By showing what mutations enable cells to avoid the deadliest consequences of malaria, the research may also point to potential treatment targets, he added.
For decades, researchers have known that people who carry a gene for sickle cell anemia are highly resistant to dying from malaria. Research has shown that it is the mutation to one of their hemoglobin genes, which codes for the oxygen-transporting protein in red blood cells, that was responsible for the fortuitous effect, and that other mutations in that same gene were also protective. But despite years of research, no one knew why.
Fairhurst and his colleagues published a paper showing that compared to normal cells, red blood cells carrying two hemoglobin mutations had lower surface concentrations of a virulent, sticky protein produced by the malaria parasite, Plasmodium falciparum. The protein, which is normally shuttled from the parasite’s protein making factory inside the cells to the cell surface, prevents the body from clearing infected blood cells. But in the blood cells with mutated hemoglobin, that didn’t seem to happen—the parasite proteins never made it to the surface of the cells.
To find out why, parasitologist Michael Lanzer of Heidelberg University in Germany and his colleagues flash froze red blood cells with and without the mutations and used electron microscopy to visualize the cells before and after infection.
They found that uninfected cells contained short pieces of actin that help keep the membrane skeleton rigid. After infection, in normal cells, long actin filaments appeared, linking a cellular component made by the parasite called the Maurer’s cleft, which looks a bit like a stack of pancakes, to the cell membrane. “We concluded that the parasite mines that actin from the membrane skeleton of the host, and uses this mined actin to generate actin filaments of its own design,” Lanzer said—namely to transmit the proteins to the outside surface of the red blood cell.
By contrast, in cells with mutated hemoglobin, the Maurer’s cleft looked more like a big blob and the disordered actin filaments did not connect the cleft to the cell membrane. Somehow, it seemed, the mutations were preventing the parasite from setting up its protein factory effectively, thereby reducing protein transport outside the cell.
The team also took a closer look at the hemoglobin, and found that  the difference between the mutated and wild-type cells was that mutated forms were more easily oxidized.  When they placed actin filaments in the presence of both the normal and mutated copies of hemoglobin, the researchers found that mutated forms of hemoglobin led to shorter actin chains than wild-type hemoglobin. Actin placed with oxidized hemoglobin similarly failed to form long chains, suggesting that oxidation was indeed responsible for the difference in the parasite’s protein machinery seen in cells with mutated and normal hemoglobin.
Taken together, the findings suggest that the hemoglobin mutations blunt the deadliness of malaria because the oxidized hemoglobin inhibits actin reorganization, thereby preventing the malaria parasite from shuttling its proteins to the surface red blood cells, Lanzer said.
Future work should confirm that the same effects are seen in cells that carry only one copy of the mutated hemoglobin, since the vast majority of people who carry these mutations and have a survival advantage against malaria are heterozygous for the mutated hemoglobin, Fairhurst said.
Understanding how the body gets around malaria’s deadliness could guide the design of drug therapies, he added, for instance by finding small molecules that inhibit the parasite’s protein trafficking machinery.
“Mother Nature had 10,000 years or so to mutate the genome in ways that would actually protect against death,” Fairhurst said. “We want to use these mutations to teach us something about how you protect children.”

EVOLUTION OF MAN

Evolution Of Man - What is it?
The modern theory concerning the evolution of man proposes that humans and apes derive from an apelike ancestor that lived on earth a few million years ago. The theory states that man, through a combination of environmental and genetic factors, emerged as a species to produce the variety of ethnicities seen today, while modern apes evolved on a separate evolutionary pathway. Perhaps the most famous proponent of evolutionary theory is Charles Darwin (1809-82) who authored The Origin of Species (1859) to describe his theory of evolution. It was based largely on observations which he made during his 5-year voyage around the world aboard the HMS Beagle (1831-36). Since then, mankind's origin has generally been explained from an evolutionary perspective. Moreover, the theory of man's evolution has been and continues to be modified as new findings are discovered, revisions to the theory are adopted, and earlier concepts proven incorrect are discarded.
Evolution Of Man - Concepts in Evolutionary Theory
The currently-accepted theory of the evolution of man rests on three major principles. These principles hinge on the innate ability which all creatures have to pass on their genetic information to their offspring through the reproductive process. An alternative explanation for homology is a common designer. According to this reasoning, the similarities in anatomical features between species point to a blueprint used by a Creator/Designer.

The first tenet is microevolution, the occurrence and build-up of mutations in the genetic sequence of an organism. Mutations are predominantly random and can occur naturally through errors in the reproductive process or through environmental impacts such as chemicals or radiation.

The second tenet of evolution is natural selection. Natural selection is a natural mechanism by which the fittest members of a species survive to pass on their genetic information, while the weakest are eliminated (die off) because they are unable to compete in the wild. Natural selection is often termed "survival of the fittest" or "elimination of the weakest."

The third tenet is speciation, which occurs when members of a species mutate to the point where they are no longer able to breed with other members of the same species. The new population becomes a reproductively isolated community that is unable to breed with its former community. Through speciation, the genes of the new population become isolated from the previous group.
Evolution Of Man - Scientific Evidence
The theory of evolution of man is supported by a set of independent observations within the fields of anthropology, paleontology, and molecular biology. Collectively, they depict life branching out from a common ancestor through gradual genetic changes over millions of years, commonly known as the "tree of life." Although accepted in mainstream science as altogether factual and experimentally proven, a closer examination of the evidences reveal some inaccuracies and reasonable alternative explanations. This causes a growing number of scientists to dissent from the Darwinian theory of evolution for its inability to satisfactorily explain the origin of man.

One of the major evidences for the evolution of man is homology, that is, the similarity of either anatomical or genetic features between species. For instance, the resemblance in the skeleton structure of apes and humans has been correlated to the homologous genetic sequences within each species as strong evidence for common ancestry. This argument contains the major assumption that similarity equals relatedness. In other words, the more alike two species appear, the more closely they are related to one another. This is known to be a poor assumption. Two species can have homologous anatomy even though they are not related in any way. This is called "convergence" in evolutionary terms. It is now known that homologous features can be generated from entirely different gene segments within different unrelated species. The reality of convergence implies that anatomical features arise because of the need for specific functionality, which is a serious blow to the concept of homology and ancestry.

Additionally, the evolution of man from ape-like ancestors is often argued on the grounds of comparative anatomy within the fossil record. Yet, the fossil record indicates more stability in the forms of species than slow or even drastic changes, which would indicate intermediate stages between modern species. The "missing links" are missing. And unfortunately, the field of paleoanthropology has been riddled with fraudulent claims of finding the missing link between humans and primates, to the extent that fragments of human skeletons have been combined with other species such as pigs and apes and passed off as legitimate. Although genetic variability is seen across all peoples, the process of natural selection leading to speciation is disputed. Research challenging the accepted paradigm continues to surface raising significant questions about the certainty of evolution as the origin of man.

Evolution Of Man - The Scrutiny
The theory concerning the evolution of man is under increased scrutiny due to the persistence of gaps in the fossil record, the inability to demonstrate "life-or-death" determining advantageous genetic mutations, and the lack of experiments or observations to truly confirm the evidence for speciation. Overall, the evolution of man pervades as the accepted paradigm on the origin of man within the scientific community. This is not because it has been proven scientifically, but because alternative viewpoints bring with them metaphysical implications which go against the modern naturalistic paradigm. Nevertheless, a closer examination of the evidence reveals evolution to be increasingly less scientific and more reliant upon beliefs, not proof.

CHART ORDER OF THE WORLDS'S HISTORTY

A BRIEF HISTORY OF THE INTERNET

The Internet was the result of some visionary thinking by people in the early 1960s who saw great potential value in allowing computers to share information on research and development in scientific and military fields. J.C.R. Licklider of MIT, first proposed a global network of computers in 1962, and moved over to the Defense Advanced Research Projects Agency (DARPA) in late 1962 to head the work to develop it. Leonard Kleinrock of MIT and later UCLA developed the theory of packet switching, which was to form the basis of Internet connections. Lawrence Roberts of MIT connected a Massachusetts computer with a California computer in 1965 over dial-up telephone lines. It showed the feasibility of wide area networking, but also showed that the telephone line's circuit switching was inadequate. Kleinrock's packet switching theory was confirmed. Roberts moved over to DARPA in 1966 and developed his plan for ARPANET. These visionaries and many more left unnamed here are the real founders of the Internet.

When the late Senator Ted Kennedy heard in 1968 that the pioneering Massachusetts company BBN had won the ARPA contract for an "interface message processor (IMP)," he sent a congratulatory telegram to BBN for their ecumenical spirit in winning the "interfaith message processor" contract.

The Internet, then known as ARPANET, was brought online in 1969 under a contract let by the renamed Advanced Research Projects Agency (ARPA) which initially connected four major computers at universities in the southwestern US (UCLA, Stanford Research Institute, UCSB, and the University of Utah). The contract was carried out by BBN of Cambridge, MA under Bob Kahn and went online in December 1969. By June 1970, MIT, Harvard, BBN, and Systems Development Corp (SDC) in Santa Monica, Cal. were added. By January 1971, Stanford, MIT's Lincoln Labs, Carnegie-Mellon, and Case-Western Reserve U were added. In months to come, NASA/Ames, Mitre, Burroughs, RAND, and the U of Illinois plugged in. After that, there were far too many to keep listing here.

Who was the first to use the Internet?

Charley Kline at UCLA sent the first packets on ARPANet as he tried to connect to Stanford Research Institute on Oct 29, 1969. The system crashed as he reached the G in LOGIN!

The Internet was designed in part to provide a communications network that would work even if some of the sites were destroyed by nuclear attack. If the most direct route was not available, routers would direct traffic around the network via alternate routes.
The early Internet was used by computer experts, engineers, scientists, and librarians. There was nothing friendly about it. There were no home or office personal computers in those days, and anyone who used it, whether a computer professional or an engineer or scientist or librarian, had to learn to use a very complex system.

Did Al Gore invent the Internet?

According to a CNN transcript of an interview with Wolf Blitzer, Al Gore said,"During my service in the United States Congress, I took the initiative in creating the Internet." Al Gore was not yet in Congress in 1969 when ARPANET started or in 1974 when the term Internet first came into use. Gore was elected to Congress in 1976. In fairness, Bob Kahn and Vint Cerf acknowledge in a paper titled Al Gore and the Internet that Gore has probably done more than any other elected official to support the growth and development of the Internet from the 1970's to the present .

E-mail was adapted for ARPANET by Ray Tomlinson of BBN in 1972. He picked the @ symbol from the available symbols on his teletype to link the username and address. The telnet protocol, enabling logging on to a remote computer, was published as a Request for Comments (RFC) in 1972. RFC's are a means of sharing developmental work throughout community. The ftp protocol, enabling file transfers between Internet sites, was published as an RFC in 1973, and from then on RFC's were available electronically to anyone who had use of the ftp protocol.
Libraries began automating and networking their catalogs in the late 1960s independent from ARPA. The visionary Frederick G. Kilgour of the Ohio College Library Center (now OCLC, Inc.) led networking of Ohio libraries during the '60s and '70s. In the mid 1970s more regional consortia from New England, the Southwest states, and the Middle Atlantic states, etc., joined with Ohio to form a national, later international, network. Automated catalogs, not very user-friendly at first, became available to the world, first through telnet or the awkward IBM variant TN3270 and only many years later, through the web. See The History of OCLC

Ethernet, a protocol for many local networks, appeared in 1974, an outgrowth of Harvard student Bob Metcalfe's dissertation on "Packet Networks." The dissertation was initially rejected by the University for not being analytical enough. It later won acceptance when he added some more equations to it.

The Internet matured in the 70's as a result of the TCP/IP architecture first proposed by Bob Kahn at BBN and further developed by Kahn and Vint Cerf at Stanford and others throughout the 70's. It was adopted by the Defense Department in 1980 replacing the earlier Network Control Protocol (NCP) and universally adopted by 1983.
The Unix to Unix Copy Protocol (UUCP) was invented in 1978 at Bell Labs. Usenet was started in 1979 based on UUCP. Newsgroups, which are discussion groups focusing on a topic, followed, providing a means of exchanging information throughout the world . While Usenet is not considered as part of the Internet, since it does not share the use of TCP/IP, it linked unix systems around the world, and many Internet sites took advantage of the availability of newsgroups. It was a significant part of the community building that took place on the networks.
Similarly, BITNET (Because It's Time Network) connected IBM mainframes around the educational community and the world to provide mail services beginning in 1981. Listserv software was developed for this network and later others. Gateways were developed to connect BITNET with the Internet and allowed exchange of e-mail, particularly for e-mail discussion lists. These listservs and other forms of e-mail discussion lists formed another major element in the community building that was taking place.
In 1986, the National Science Foundation funded NSFNet as a cross country 56 Kbps backbone for the Internet. They maintained their sponsorship for nearly a decade, setting rules for its non-commercial government and research uses.
As the commands for e-mail, FTP, and telnet were standardized, it became a lot easier for non-technical people to learn to use the nets. It was not easy by today's standards by any means, but it did open up use of the Internet to many more people in universities in particular. Other departments besides the libraries, computer, physics, and engineering departments found ways to make good use of the nets--to communicate with colleagues around the world and to share files and resources.
While the number of sites on the Internet was small, it was fairly easy to keep track of the resources of interest that were available. But as more and more universities and organizations--and their libraries-- connected, the Internet became harder and harder to track. There was more and more need for tools to index the resources that were available.
The first effort, other than library catalogs, to index the Internet was created in 1989, as Peter Deutsch and his crew at McGill University in Montreal, created an archiver for ftp sites, which they named Archie. This software would periodically reach out to all known openly available ftp sites, list their files, and build a searchable index of the software. The commands to search Archie were unix commands, and it took some knowledge of unix to use it to its full capability.

McGill University, which hosted the first Archie, found out one day that half the Internet traffic going into Canada from the United States was accessing Archie. Administrators were concerned that the University was subsidizing such a volume of traffic, and closed down Archie to outside access. Fortunately, by that time, there were many more Archies available.

At about the same time, Brewster Kahle, then at Thinking Machines, Corp. developed his Wide Area Information Server (WAIS), which would index the full text of files in a database and allow searches of the files. There were several versions with varying degrees of complexity and capability developed, but the simplest of these were made available to everyone on the nets. At its peak, Thinking Machines maintained pointers to over 600 databases around the world which had been indexed by WAIS. They included such things as the full set of Usenet Frequently Asked Questions files, the full documentation of working papers such as RFC's by those developing the Internet's standards, and much more. Like Archie, its interface was far from intuitive, and it took some effort to learn to use it well.
Peter Scott of the University of Saskatchewan, recognizing the need to bring together information about all the telnet-accessible library catalogs on the web, as well as other telnet resources, brought out his Hytelnet catalog in 1990. It gave a single place to get information about library catalogs and other telnet resources and how to use them. He maintained it for years, and added HyWebCat in 1997 to provide information on web-based catalogs.
In 1991, the first really friendly interface to the Internet was developed at the University of Minnesota. The University wanted to develop a simple menu system to access files and information on campus through their local network. A debate followed between mainframe adherents and those who believed in smaller systems with client-server architecture. The mainframe adherents "won" the debate initially, but since the client-server advocates said they could put up a prototype very quickly, they were given the go-ahead to do a demonstration system. The demonstration system was called a gopher after the U of Minnesota mascot--the golden gopher. The gopher proved to be very prolific, and within a few years there were over 10,000 gophers around the world. It takes no knowledge of unix or computer architecture to use. In a gopher system, you type or click on a number to select the menu selection you want.
Gopher's usability was enhanced much more when the University of Nevada at Reno developed the VERONICA searchable index of gopher menus. It was purported to be an acronym for Very Easy Rodent-Oriented Netwide Index to Computerized Archives. A spider crawled gopher menus around the world, collecting links and retrieving them for the index. It was so popular that it was very hard to connect to, even though a number of other VERONICA sites were developed to ease the load. Similar indexing software was developed for single sites, called JUGHEAD (Jonzy's Universal Gopher Hierarchy Excavation And Display).

Peter Deutsch, who developed Archie, always insisted that Archie was short for Archiver, and had nothing to do with the comic strip. He was disgusted when VERONICA and JUGHEAD appeared.

In 1989 another significant event took place in making the nets easier to use. Tim Berners-Lee and others at the European Laboratory for Particle Physics, more popularly known as CERN, proposed a new protocol for information distribution. This protocol, which became the World Wide Web in 1991, was based on hypertext--a system of embedding links in text to link to other text, which you have been using every time you selected a text link while reading these pages. Although started before gopher, it was slower to develop.
The development in 1993 of the graphical browser Mosaic by Marc Andreessen and his team at the National Center For Supercomputing Applications (NCSA) gave the protocol its big boost. Later, Andreessen moved to become the brains behind Netscape Corp., which produced the most successful graphical type of browser and server until Microsoft declared war and developed its MicroSoft Internet Explorer.

MICHAEL DERTOUZOS
1936-2001

The early days of the web was a confused period as many developers tried to put their personal stamp on ways the web should develop. The web was threatened with becoming a mass of unrelated protocols that would require different software for different applications. The visionary Michael Dertouzos of MIT's Laboratory for Computer Sciences persuaded Tim Berners-Lee and others to form the World Wide Web Consortium in 1994 to promote and develop standards for the Web. Proprietary plug-ins still abound for the web, but the Consortium has ensured that there are common standards present in every browser.
Read Tim Berners-Lee's tribute to Michael Dertouzos.

Since the Internet was initially funded by the government, it was originally limited to research, education, and government uses. Commercial uses were prohibited unless they directly served the goals of research and education. This policy continued until the early 90's, when independent commercial networks began to grow. It then became possible to route traffic across the country from one commercial site to another without passing through the government funded NSFNet Internet backbone.
Delphi was the first national commercial online service to offer Internet access to its subscribers. It opened up an email connection in July 1992 and full Internet service in November 1992. All pretenses of limitations on commercial use disappeared in May 1995 when the National Science Foundation ended its sponsorship of the Internet backbone, and all traffic relied on commercial networks. AOL, Prodigy, and CompuServe came online. Since commercial usage was so widespread by this time and educational institutions had been paying their own way for some time, the loss of NSF funding had no appreciable effect on costs.
Today, NSF funding has moved beyond supporting the backbone and higher educational institutions to building the K-12 and local public library accesses on the one hand, and the research on the massive high volume connections on the other.
Microsoft's full scale entry into the browser, server, and Internet Service Provider market completed the major shift over to a commercially based Internet. The release of Windows 98 in June 1998 with the Microsoft browser well integrated into the desktop shows Bill Gates' determination to capitalize on the enormous growth of the Internet. Microsoft's success over the past few years has brought court challenges to their dominance. We'll leave it up to you whether you think these battles should be played out in the courts or the marketplace.
During this period of enormous growth, businesses entering the Internet arena scrambled to find economic models that work. Free services supported by advertising shifted some of the direct costs away from the consumer--temporarily. Services such as Delphi offered free web pages, chat rooms, and message boards for community building. Online sales have grown rapidly for such products as books and music CDs and computers, but the profit margins are slim when price comparisons are so easy, and public trust in online security is still shaky. Business models that have worked well are portal sites, that try to provide everything for everybody, and live auctions. AOL's acquisition of Time-Warner was the largest merger in history when it took place and shows the enormous growth of Internet business! The stock market has had a rocky ride, swooping up and down as the new technology companies, the dot.com's encountered good news and bad. The decline in advertising income spelled doom for many dot.coms, and a major shakeout and search for better business models took place by the survivors.
A current trend with major implications for the future is the growth of high speed connections. 56K modems and the providers who supported them spread widely for a while, but this is the low end now. 56K is not fast enough to carry multimedia, such as sound and video except in low quality. But new technologies many times faster, such as cablemodems and digital subscriber lines (DSL) are predominant now.
Wireless has grown rapidly in the past few years, and travellers search for the wi-fi "hot spots" where they can connect while they are away from the home or office. Many airports, coffee bars, hotels and motels now routinely provide these services, some for a fee and some for free.
A next big growth area is the surge towards universal wireless access, where almost everywhere is a "hot spot". Municipal wi-fi or city-wide access, wiMAX offering broader ranges than wi-fi, EV-DO, 4g, and other formats will joust for dominance in the USA in the years ahead. The battle is both economic and political.
Another trend that is rapidly affecting web designers is the growth of smaller devices to connect to the Internet. Small tablets, pocket PCs, smart phones, ebooks, game machines, and even GPS devices are now capable of tapping into the web on the go, and many web pages are not designed to work on that scale.
As the Internet has become ubiquitous, faster, and increasingly accessible to non-technical communities, social networking and collaborative services have grown rapidly, enabling people to communicate and share interests in many more ways. Sites like Facebook, Twitter, Linked-In, YouTube, Flickr, Second Life, delicious, blogs, wikis, and many more let people of all ages rapidly share their interests of the moment with others everywhere.
As Heraclitus said in the 4th century BC, "Nothing is permanent, but change!"
May you live in interesting times! (ostensibly an ancient Chinese curse)

IMAGE FOR SOLAR SYSTEM

THE HUMAN SKELETON

Gordon Dam

THE HUMAN HEARTH

The Human Heart

The heart is one of the most important organs in the entire human body. It is really nothing more than a pump, composed of muscle which pumps blood throughout the body, beating approximately 72 times per minute of our lives. The heart pumps the blood, which carries all the vital materials which help our bodies function and removes the waste products that we do not need. For example, the brain requires oxygen and glucose, which, if not received continuously, will cause it to loose consciousness. Muscles need oxygen, glucose and amino acids, as well as the proper ratio of sodium, calcium and potassium salts in order to contract normally. The glands need sufficient supplies of raw materials from which to manufacture the specific secretions. If the heart ever ceases to pump blood the body begins to shut down and after a very short period of time will die.

The heart is essentially a muscle(a little larger than the fist). Like any other muscle in the human body, it contracts and expands. Unlike skeletal muscles, however, the heart works on the "All -or-Nothing Law". That is, each time the heart contracts it does so with all its force. In skeletal muscles, the principle of "gradation" is present. The pumping of the heart is called the Cardiac Cycle, which occurs about 72 times per minute. This means that each cycle lasts about eight-tenths of a second. During this cycle the entire heart actually rests for about four-tenths of a second.

Make-up of the Heart.

The walls of the heart are made up of three layers, while the cavity is divided into four parts. There are two upper chambers, called the right and left atria, and two lower chambers, called the right and left ventricles. The Right Atrium, as it is called, receives blood from the upper and lower body through the superior vena cava and the inferior vena cava, respectively, and from the heart muscle itself through the coronary sinus. The right atrium is the larger of the two atria, having very thin walls. The right atrium opens into the right ventricle through the right atrioventicular valve(tricuspid), which only allows the blood to flow from the atria into the ventricle, but not in the reverse direction. The right ventricle pumps the blood to the lungs to be reoxygenated. The left atrium receives blood from the lungs via the four pulmonary veins. It is smaller than the right atrium, but has thicker walls. The valve between the left atrium and the left ventricle, the left atrioventicular valve(bicuspid), is smaller than the tricuspid. It opens into the left ventricle and again is a one way valve. The left ventricle pumps the blood throughout the body. It is the Aorta, the largest artery in the body, which originates from the left ventricle.

The Heart works as a pump moving blood around in our bodies to nourish every cell. Used blood, that is blood that has already been to the cells and has given up its nutrients to them, is drawn from the body by the right half of the heart, and then sent to the lungs to be reoxygenated. Blood that has been reoxygenated by the lungs is drawn into the left side of the heart and then pumped into the blood stream. It is the atria that draw the blood from the lungs and body, and the ventricles that pump it to the lungs and body. The output of each ventricle per beat is about 70 ml, or about 2 tablespoons. In a trained athlete this amount is about double. With the average heart rate of 72 beats per minute the heart will pump about 5 litres per ventricle, or about 10 litres total per minute. This is called the cardiac output. In a trained athlete the total cardiac output is about 20 litres. If we multiply the normal, non-athlete output by the average age of 70 years, we see that the cardiac output of the average human heart over a life time would be about 1 million litres, or about 250,000 gallons(US).

HIV/AIDS

Acquired immune deficiency syndrome or acquired immunodeficiency syndrome (AIDS) is a disease of the human immune system caused by the human immunodeficiency virus (HIV).^[1][2][3] This condition progressively reduces the effectiveness of the immune system and leaves individuals susceptible to opportunistic infections and tumors. HIV is transmitted through direct contact of a mucous membrane or the bloodstream with a bodily fluid containing HIV, such as blood, semen, vaginal fluid, preseminal fluid, and breast milk.^[4][5] This transmission can involve anal, vaginal or oral sex, blood transfusion, contaminated hypodermic needles, exchange between mother and baby during pregnancy, childbirth, breastfeeding or other exposure to one of the above bodily fluids.
AIDS is now a pandemic.^[6] As of 2009, the World Health Organization (WHO) estimated that there are 33.3 million people worldwide living with HIV/AIDS, with 2.6 million new HIV infections per year and 1.8 million annual deaths due to AIDS.^[7]In 2007, UNAIDS estimated: 33.2 million people worldwide had AIDS that year; AIDS killed 2.1 million people in the course of that year, including 330,000 children, and 76% of those deaths occurred in sub-Saharan Africa.^[8] According to UNAIDS 2009 report, worldwide some 60 million people have been infected, with some 25 million deaths, and 14 million orphaned children in southern Africa alone since the epidemic began.^[9]
Genetic research indicates that HIV originated in west-central Africa during the late nineteenth or early twentieth century.^[10][11] AIDS was first recognized by the U.S. Centers for Disease Control and Prevention in 1981 and its cause, HIV, identified in the early 1980s.^[12]

Although treatments for AIDS and HIV can slow the course of the disease, there is no known cure or vaccine. Antiretroviral treatment reduces both the mortality and the morbidity of HIV infection, but these drugs are expensive and routine access to antiretroviral medication is not available in all countries.^[13] Due to the difficulty in treating HIV infection, preventing infection is a key aim in controlling the AIDS pandemic, with health organizations promoting safe sex and needle-exchange programmes in attempts to slow the spread of the virus.

Anatomy, Physiology & Pathology of the Human Eye

The human eye is the organ which gives us the sense of sight, allowing us to observe and learn more about the surrounding world than we do with any of the other four senses.  We use our eyes in almost every activity we perform, whether reading, working, watching television, writing a letter, driving a car, and in countless other ways.  Most people probably would agree that sight is the sense they value more than all the rest.
The eye allows us to see and interpret the shapes, colors, and dimensions of objects in the world by processing the light they reflect or emit.  The eye is able to detect bright light or dim light, but it cannot sense objects when light is absent.

process of vision

Light waves from an object (such as a tree) enter the eye first through the cornea, which is the clear dome at the front of the eye.  The light then progresses through the pupil, the circular opening in the center of the colored iris.
Fluctuations in incoming light change the size of the eye’s pupil.  When the light entering the eye is bright enough, the pupil will constrict (get smaller), due to the pupillary light response.
Initially, the light waves are bent or converged first by the cornea, and then further by the crystalline lens (located immediately behind the iris and the pupil), to a nodal point (N) located immediately behind the back surface of the lens.  At that point, the image becomes reversed (turned backwards) and inverted (turned upside-down).
The light continues through the vitreous humor, the clear gel that makes up about 80% of the eye’s volume, and then, ideally, back to a clear focus on the retina, behind the vitreous.  The small central area of the retina is the macula, which provides the best vision of any location in the retina.  If the eye is considered to be a type of camera (albeit, an extremely complex one), the retina is equivalent to the film inside of the camera, registering the tiny photons of light interacting with it.
Within the layers of the retina, light impulses are changed into electrical signals.  Then they are sent through the optic nerve, along the visual pathway, to the occipital cortex at the posterior (back) of the brain.  Here, the electrical signals are interpreted or “seen” by the brain as a visual image.
Actually, then, we do not “see” with our eyes but, rather, with our brains.  Our eyes merely are the beginnings of the visual process.

myopia, hyperopia, astigmatism

If the incoming light from a far away object focuses before it gets to the back of the eye, that eye’s refractive error is called “myopia” (nearsightedness).  If incoming light from something far away has not focused by the time it reaches the back of the eye, that eye’s refractive error is “hyperopia” (farsightedness).
In the case of “astigmatism,” one or more surfaces of the cornea or lens (the eye structures which focus incoming light) are not spherical (shaped like the side of a basketball) but, instead, are cylindrical or toric (shaped a bit like the side of a football).  As a result, there is no distinct point of focus inside the eye but, rather, a smeared or spread-out focus.  Astigmatism is the most common refractive error.

presbyopia (“after 40” vision)

After age 40, and most noticeably after age 45, the human eye is affected by presbyopia.  This natural condition results in greater difficulty maintaining a clear focus at a near distance with an eye which sees clearly far away.
Presbyopia is caused by a lessening of flexibility of the crystalline lens, as well as to a weakening of the ciliary muscles which control lens focusing.  Both are attributable to the aging process.
An eye can see clearly at a far distance naturally, or it can be made to see clearly artificially, such as with the aid of eyeglasses or contact lenses, or else following a photorefractive procedure such as LASIK (laser-assisted in situ keratomileusis).  Nevertheless, presbyopia eventually will affect the near focusing of every human eye.

eye growth

The average newborn’s eyeball is about 18 millimeters in diameter, from front to back (axial length).  In an infant, the eye grows slightly to a length of approximately 19½ millimeters.
The eye continues to grow, gradually, to a length of about 24-25 millimeters, or about 1 inch, in adulthood.  A ping-pong ball is about 1½ inch in diameter, which makes the average adult eyeball about 2/3 the size of a ping-pong ball.
The eyeball is set in a protective cone-shaped cavity in the skull called the “orbit” or “socket.”  This bony orbit also enlarges as the eye grows.

extraocular muscles

The orbit is surrounded by layers of soft, fatty tissue.  These layers protect the eye and enable it to turn easily.
Traversing the fatty tissue are three pairs of extraocular muscles, which regulate the motion of each eye: the medial & lateral rectus muscles, the superior & inferior rectus muscles, and the superior & inferior oblique muscles.

eye structures

Several structures compose the human eye.  Among the most important anatomical components are the cornea, conjunctiva, iris, crystalline lens, vitreous humor, retina, macula, optic nerve, and extraocular muscles

ANATOMY OF THE BRAIN

The anatomy of the brain is complex due its intricate structure and function. This amazing organ acts as a control center by receiving, interpreting, and directing sensory information throughout the body. There are three major divisions of the brain. They are the forebrain, the midbrain, and the hindbrain.

Anatomy of the Brain: Brain Divisions

The forebrain is responsible for a variety of functions including receiving and processing sensory information, thinking, perceiving, producing and understanding language, and controlling motor function. There are two major divisions of forebrain: the diencephalon and the telencephalon. The diencephalon contains structures such as the thalamus and hypothalamus which are responsible for such functions as motor control, relaying sensory information, and controlling autonomic functions. The telencephalon contains the largest part of the brain, the cerebrum. Most of the actual information processing in the brain takes place in the cerebral cortex.

The midbrain and the hindbrain together make up the brainstem. The midbrain is the portion of the brainstem that connects the hindbrain and the forebrain. This region of the brain is involved in auditory and visual responses as well as motor function.

The hindbrain extends from the spinal cord and is composed of the metencephalon and myelencephalon. The metencephalon contains structures such as the pons and cerebellum. These regions assists in maintaining balance and equilibrium, movement coordination, and the conduction of sensory information. The myelencephalon is composed of the medulla oblongata which is responsible for controlling such autonomic functions as breathing, heart rate, and digestion.

ESTROGE NEW ROLE

Neuroscientists at the University of Massachusetts, Amherst (UMass), and the University of California, Los Angeles, have found that estrogen can act as a neurotransmitter, in addition to its usual role as a hormone in the bloodstream, according to a study published in the Journal of Neuroscience last month.
Estradiol—the type of estrogen that is most prevalent in the body during a female’s reproductive years—is produced by the ovaries and then enters the blood stream where it takes hours or days to bring about changes in the cortex region of the brain. But in of zebra finches, neurons also produced estradiol directly inside the presynaptic terminal. Within a matter of seconds, the hormone then crossed the synapses of the auditory forebrain—the area of the brain that responds to sound.

This is “similar to the way neurotransmitters are controlled,” Luke Remage-Healey, neuroscientist at UMass, said in a press release.
This is the first time that scientists have directly measured estrogen levels over a short period of time in the brain of a live animal to determine how estradiol is produced and transmitted between neurons. Because of the brain’s ability to produce it quickly and in a precise location, Remage-Healey and his colleagues believe that estradiol, which is known to play a role in memory, cognition, and neuroplasticity, may someday be a target to improve brain function.

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