Friday 19 August 2011
Friday 12 August 2011
THE HUMAN HEARTH
The Human Heart
The heart is one of the most important organs in the entire human body. It is really nothing more than a pump, composed of muscle which pumps blood throughout the body, beating approximately 72 times per minute of our lives. The heart pumps the blood, which carries all the vital materials which help our bodies function and removes the waste products that we do not need. For example, the brain requires oxygen and glucose, which, if not received continuously, will cause it to loose consciousness. Muscles need oxygen, glucose and amino acids, as well as the proper ratio of sodium, calcium and potassium salts in order to contract normally. The glands need sufficient supplies of raw materials from which to manufacture the specific secretions. If the heart ever ceases to pump blood the body begins to shut down and after a very short period of time will die.
Make-up of the Heart.
The walls of the heart are made up of three layers, while the cavity is divided into four parts. There are two upper chambers, called the right and left atria, and two lower chambers, called the right and left ventricles. The Right Atrium, as it is called, receives blood from the upper and lower body through the superior vena cava and the inferior vena cava, respectively, and from the heart muscle itself through the coronary sinus. The right atrium is the larger of the two atria, having very thin walls. The right atrium opens into the right ventricle through the right atrioventicular valve(tricuspid), which only allows the blood to flow from the atria into the ventricle, but not in the reverse direction. The right ventricle pumps the blood to the lungs to be reoxygenated. The left atrium receives blood from the lungs via the four pulmonary veins. It is smaller than the right atrium, but has thicker walls. The valve between the left atrium and the left ventricle, the left atrioventicular valve(bicuspid), is smaller than the tricuspid. It opens into the left ventricle and again is a one way valve. The left ventricle pumps the blood throughout the body. It is the Aorta, the largest artery in the body, which originates from the left ventricle. 
The Heart works as a pump moving blood around in our bodies to nourish every cell. Used blood, that is blood that has already been to the cells and has given up its nutrients to them, is drawn from the body by the right half of the heart, and then sent to the lungs to be reoxygenated. Blood that has been reoxygenated by the lungs is drawn into the left side of the heart and then pumped into the blood stream. It is the atria that draw the blood from the lungs and body, and the ventricles that pump it to the lungs and body. The output of each ventricle per beat is about 70 ml, or about 2 tablespoons. In a trained athlete this amount is about double. With the average heart rate of 72 beats per minute the heart will pump about 5 litres per ventricle, or about 10 litres total per minute. This is called the cardiac output. In a trained athlete the total cardiac output is about 20 litres. If we multiply the normal, non-athlete output by the average age of 70 years, we see that the cardiac output of the average human heart over a life time would be about 1 million litres, or about 250,000 gallons(US).
Friday 5 August 2011
HIV/AIDS
Acquired immune deficiency syndrome or acquired immunodeficiency syndrome (AIDS) is a disease of the human immune system caused by the human immunodeficiency virus (HIV).[1][2][3] This condition progressively reduces the effectiveness of the immune system and leaves individuals susceptible to opportunistic infections and tumors. HIV is transmitted through direct contact of a mucous membrane or the bloodstream with a bodily fluid containing HIV, such as blood, semen, vaginal fluid, preseminal fluid, and breast milk.[4][5] This transmission can involve anal, vaginal or oral sex, blood transfusion, contaminated hypodermic needles, exchange between mother and baby during pregnancy, childbirth, breastfeeding or other exposure to one of the above bodily fluids.
AIDS is now a pandemic.[6] As of 2009, the World Health Organization (WHO) estimated that there are 33.3 million people worldwide living with HIV/AIDS, with 2.6 million new HIV infections per year and 1.8 million annual deaths due to AIDS.[7]In 2007, UNAIDS estimated: 33.2 million people worldwide had AIDS that year; AIDS killed 2.1 million people in the course of that year, including 330,000 children, and 76% of those deaths occurred in sub-Saharan Africa.[8] According to UNAIDS 2009 report, worldwide some 60 million people have been infected, with some 25 million deaths, and 14 million orphaned children in southern Africa alone since the epidemic began.[9]
Genetic research indicates that HIV originated in west-central Africa during the late nineteenth or early twentieth century.[10][11] AIDS was first recognized by the U.S. Centers for Disease Control and Prevention in 1981 and its cause, HIV, identified in the early 1980s.[12]
Although treatments for AIDS and HIV can slow the course of the disease, there is no known cure or vaccine. Antiretroviral treatment reduces both the mortality and the morbidity of HIV infection, but these drugs are expensive and routine access to antiretroviral medication is not available in all countries.[13] Due to the difficulty in treating HIV infection, preventing infection is a key aim in controlling the AIDS pandemic, with health organizations promoting safe sex and needle-exchange programmes in attempts to slow the spread of the virus.
AIDS is now a pandemic.[6] As of 2009, the World Health Organization (WHO) estimated that there are 33.3 million people worldwide living with HIV/AIDS, with 2.6 million new HIV infections per year and 1.8 million annual deaths due to AIDS.[7]In 2007, UNAIDS estimated: 33.2 million people worldwide had AIDS that year; AIDS killed 2.1 million people in the course of that year, including 330,000 children, and 76% of those deaths occurred in sub-Saharan Africa.[8] According to UNAIDS 2009 report, worldwide some 60 million people have been infected, with some 25 million deaths, and 14 million orphaned children in southern Africa alone since the epidemic began.[9]
Genetic research indicates that HIV originated in west-central Africa during the late nineteenth or early twentieth century.[10][11] AIDS was first recognized by the U.S. Centers for Disease Control and Prevention in 1981 and its cause, HIV, identified in the early 1980s.[12]
Anatomy, Physiology & Pathology of the Human Eye
The human eye is the organ which gives us the sense of sight, allowing us to observe and learn more about the surrounding world than we do with any of the other four senses. We use our eyes in almost every activity we perform, whether reading, working, watching television, writing a letter, driving a car, and in countless other ways. Most people probably would agree that sight is the sense they value more than all the rest.
The eye allows us to see and interpret the shapes, colors, and dimensions of objects in the world by processing the light they reflect or emit. The eye is able to detect bright light or dim light, but it cannot sense objects when light is absent.
Light waves from an object (such as a tree) enter the eye first through the cornea, which is the clear dome at the front of the eye. The light then progresses through the pupil, the circular opening in the center of the colored iris.
Fluctuations in incoming light change the size of the eye’s pupil. When the light entering the eye is bright enough, the pupil will constrict (get smaller), due to the pupillary light response.
Initially, the light waves are bent or converged first by the cornea, and then further by the crystalline lens (located immediately behind the iris and the pupil), to a nodal point (N) located immediately behind the back surface of the lens. At that point, the image becomes reversed (turned backwards) and inverted (turned upside-down).
The light continues through the vitreous humor, the clear gel that makes up about 80% of the eye’s volume, and then, ideally, back to a clear focus on the retina, behind the vitreous. The small central area of the retina is the macula, which provides the best vision of any location in the retina. If the eye is considered to be a type of camera (albeit, an extremely complex one), the retina is equivalent to the film inside of the camera, registering the tiny photons of light interacting with it.
Within the layers of the retina, light impulses are changed into electrical signals. Then they are sent through the optic nerve, along the visual pathway, to the occipital cortex at the posterior (back) of the brain. Here, the electrical signals are interpreted or “seen” by the brain as a visual image.
Actually, then, we do not “see” with our eyes but, rather, with our brains. Our eyes merely are the beginnings of the visual process.
In the case of “astigmatism,” one or more surfaces of the cornea or lens (the eye structures which focus incoming light) are not spherical (shaped like the side of a basketball) but, instead, are cylindrical or toric (shaped a bit like the side of a football). As a result, there is no distinct point of focus inside the eye but, rather, a smeared or spread-out focus. Astigmatism is the most common refractive error.
Presbyopia is caused by a lessening of flexibility of the crystalline lens, as well as to a weakening of the ciliary muscles which control lens focusing. Both are attributable to the aging process.
An eye can see clearly at a far distance naturally, or it can be made to see clearly artificially, such as with the aid of eyeglasses or contact lenses, or else following a photorefractive procedure such as LASIK (laser-assisted in situ keratomileusis). Nevertheless, presbyopia eventually will affect the near focusing of every human eye.
The eye continues to grow, gradually, to a length of about 24-25 millimeters, or about 1 inch, in adulthood. A ping-pong ball is about 1½ inch in diameter, which makes the average adult eyeball about 2/3 the size of a ping-pong ball.
The eyeball is set in a protective cone-shaped cavity in the skull called the “orbit” or “socket.” This bony orbit also enlarges as the eye grows.
Traversing the fatty tissue are three pairs of extraocular muscles, which regulate the motion of each eye: the medial & lateral rectus muscles, the superior & inferior rectus muscles, and the superior & inferior oblique muscles.
The eye allows us to see and interpret the shapes, colors, and dimensions of objects in the world by processing the light they reflect or emit. The eye is able to detect bright light or dim light, but it cannot sense objects when light is absent.
process of vision
Light waves from an object (such as a tree) enter the eye first through the cornea, which is the clear dome at the front of the eye. The light then progresses through the pupil, the circular opening in the center of the colored iris.Fluctuations in incoming light change the size of the eye’s pupil. When the light entering the eye is bright enough, the pupil will constrict (get smaller), due to the pupillary light response.
Initially, the light waves are bent or converged first by the cornea, and then further by the crystalline lens (located immediately behind the iris and the pupil), to a nodal point (N) located immediately behind the back surface of the lens. At that point, the image becomes reversed (turned backwards) and inverted (turned upside-down).
The light continues through the vitreous humor, the clear gel that makes up about 80% of the eye’s volume, and then, ideally, back to a clear focus on the retina, behind the vitreous. The small central area of the retina is the macula, which provides the best vision of any location in the retina. If the eye is considered to be a type of camera (albeit, an extremely complex one), the retina is equivalent to the film inside of the camera, registering the tiny photons of light interacting with it.
Within the layers of the retina, light impulses are changed into electrical signals. Then they are sent through the optic nerve, along the visual pathway, to the occipital cortex at the posterior (back) of the brain. Here, the electrical signals are interpreted or “seen” by the brain as a visual image.
Actually, then, we do not “see” with our eyes but, rather, with our brains. Our eyes merely are the beginnings of the visual process.
myopia, hyperopia, astigmatism
If the incoming light from a far away object focuses before it gets to the back of the eye, that eye’s refractive error is called “myopia” (nearsightedness). If incoming light from something far away has not focused by the time it reaches the back of the eye, that eye’s refractive error is “hyperopia” (farsightedness).In the case of “astigmatism,” one or more surfaces of the cornea or lens (the eye structures which focus incoming light) are not spherical (shaped like the side of a basketball) but, instead, are cylindrical or toric (shaped a bit like the side of a football). As a result, there is no distinct point of focus inside the eye but, rather, a smeared or spread-out focus. Astigmatism is the most common refractive error.
presbyopia (“after 40” vision)
After age 40, and most noticeably after age 45, the human eye is affected by presbyopia. This natural condition results in greater difficulty maintaining a clear focus at a near distance with an eye which sees clearly far away.Presbyopia is caused by a lessening of flexibility of the crystalline lens, as well as to a weakening of the ciliary muscles which control lens focusing. Both are attributable to the aging process.
An eye can see clearly at a far distance naturally, or it can be made to see clearly artificially, such as with the aid of eyeglasses or contact lenses, or else following a photorefractive procedure such as LASIK (laser-assisted in situ keratomileusis). Nevertheless, presbyopia eventually will affect the near focusing of every human eye.
eye growth
The average newborn’s eyeball is about 18 millimeters in diameter, from front to back (axial length). In an infant, the eye grows slightly to a length of approximately 19½ millimeters.The eye continues to grow, gradually, to a length of about 24-25 millimeters, or about 1 inch, in adulthood. A ping-pong ball is about 1½ inch in diameter, which makes the average adult eyeball about 2/3 the size of a ping-pong ball.
The eyeball is set in a protective cone-shaped cavity in the skull called the “orbit” or “socket.” This bony orbit also enlarges as the eye grows.
extraocular muscles
The orbit is surrounded by layers of soft, fatty tissue. These layers protect the eye and enable it to turn easily.Traversing the fatty tissue are three pairs of extraocular muscles, which regulate the motion of each eye: the medial & lateral rectus muscles, the superior & inferior rectus muscles, and the superior & inferior oblique muscles.
eye structures
Several structures compose the human eye. Among the most important anatomical components are the cornea, conjunctiva, iris, crystalline lens, vitreous humor, retina, macula, optic nerve, and extraocular musclesThursday 4 August 2011
ANATOMY OF THE BRAIN
Anatomy of the Brain: Brain Divisions
The forebrain is responsible for a variety of functions including receiving and processing sensory information, thinking, perceiving, producing and understanding language, and controlling motor function. There are two major divisions of forebrain: the diencephalon and the telencephalon. The diencephalon contains structures such as the thalamus and hypothalamus which are responsible for such functions as motor control, relaying sensory information, and controlling autonomic functions. The telencephalon contains the largest part of the brain, the cerebrum. Most of the actual information processing in the brain takes place in the cerebral cortex.The midbrain and the hindbrain together make up the brainstem. The midbrain is the portion of the brainstem that connects the hindbrain and the forebrain. This region of the brain is involved in auditory and visual responses as well as motor function.
The hindbrain extends from the spinal cord and is composed of the metencephalon and myelencephalon. The metencephalon contains structures such as the pons and cerebellum. These regions assists in maintaining balance and equilibrium, movement coordination, and the conduction of sensory information. The myelencephalon is composed of the medulla oblongata which is responsible for controlling such autonomic functions as breathing, heart rate, and digestion.
ESTROGE NEW ROLE
Estradiol—the type of estrogen that is most prevalent in the body during a female’s reproductive years—is produced by the ovaries and then enters the blood stream where it takes hours or days to bring about changes in the cortex region of the brain. But in of zebra finches, neurons also produced estradiol directly inside the presynaptic terminal. Within a matter of seconds, the hormone then crossed the synapses of the auditory forebrain—the area of the brain that responds to sound.
This is the first time that scientists have directly measured estrogen levels over a short period of time in the brain of a live animal to determine how estradiol is produced and transmitted between neurons. Because of the brain’s ability to produce it quickly and in a precise location, Remage-Healey and his colleagues believe that estradiol, which is known to play a role in memory, cognition, and neuroplasticity, may someday be a target to improve brain function.
DARWIN THEORY OF EVOLUTION
Darwin's Theory of Evolution - The Premise
Darwin's Theory of Evolution is the widely held notion that all life is related and has descended from a common ancestor: the birds and the bananas, the fishes and the flowers -- all related. Darwin's general theory presumes the development of life from non-life and stresses a purely naturalistic (undirected) "descent with modification". That is, complex creatures evolve from more simplistic ancestors naturally over time. In a nutshell, as random genetic mutations occur within an organism's genetic code, the beneficial mutations are preserved because they aid survival -- a process known as "natural selection." These beneficial mutations are passed on to the next generation. Over time, beneficial mutations accumulate and the result is an entirely different organism (not just a variation of the original, but an entirely different creature).
Darwin's Theory of Evolution - Natural Selection
While Darwin's Theory of Evolution is a relatively young archetype, the evolutionary worldview itself is as old as antiquity. Ancient Greek philosophers such as Anaximander postulated the development of life from non-life and the evolutionary descent of man from animal. Charles Darwin simply brought something new to the old philosophy -- a plausible mechanism called "natural selection." Natural selection acts to preserve and accumulate minor advantageous genetic mutations. Suppose a member of a species developed a functional advantage (it grew wings and learned to fly). Its offspring would inherit that advantage and pass it on to their offspring. The inferior (disadvantaged) members of the same species would gradually die out, leaving only the superior (advantaged) members of the species. Natural selection is the preservation of a functional advantage that enables a species to compete better in the wild. Natural selection is the naturalistic equivalent to domestic breeding. Over the centuries, human breeders have produced dramatic changes in domestic animal populations by selecting individuals to breed. Breeders eliminate undesirable traits gradually over time. Similarly, natural selection eliminates inferior species gradually over time.
Darwin's Theory of Evolution - Slowly But Surely...
Darwin's Theory of Evolution is a slow gradual process. Darwin wrote, "…Natural selection acts only by taking advantage of slight successive variations; she can never take a great and sudden leap, but must advance by short and sure, though slow steps." [1] Thus, Darwin conceded that, "If it could be demonstrated that any complex organ existed, which could not possibly have been formed by numerous, successive, slight modifications, my theory would absolutely break down." [2] Such a complex organ would be known as an "irreducibly complex system". An irreducibly complex system is one composed of multiple parts, all of which are necessary for the system to function. If even one part is missing, the entire system will fail to function. Every individual part is integral. [3] Thus, such a system could not have evolved slowly, piece by piece. The common mousetrap is an everyday non-biological example of irreducible complexity. It is composed of five basic parts: a catch (to hold the bait), a powerful spring, a thin rod called "the hammer," a holding bar to secure the hammer in place, and a platform to mount the trap. If any one of these parts is missing, the mechanism will not work. Each individual part is integral. The mousetrap is irreducibly complex. [4]
Darwin's Theory of Evolution - A Theory In Crisis
Darwin's Theory of Evolution is a theory in crisis in light of the tremendous advances we've made in molecular biology, biochemistry and genetics over the past fifty years. We now know that there are in fact tens of thousands of irreducibly complex systems on the cellular level. Specified complexity pervades the microscopic biological world. Molecular biologist Michael Denton wrote, "Although the tiniest bacterial cells are incredibly small, weighing less than 10-12 grams, each is in effect a veritable micro-miniaturized factory containing thousands of exquisitely designed pieces of intricate molecular machinery, made up altogether of one hundred thousand million atoms, far more complicated than any machinery built by man and absolutely without parallel in the non-living world." [5]
And we don't need a microscope to observe irreducible complexity. The eye, the ear and the heart are all examples of irreducible complexity, though they were not recognized as such in Darwin's day. Nevertheless, Darwin confessed, "To suppose that the eye with all its inimitable contrivances for adjusting the focus to different distances, for admitting different amounts of light, and for the correction of spherical and chromatic aberration, could have been formed by natural selection, seems, I freely confess, absurd in the highest degree." [6]
Darwin's Theory of Evolution is the widely held notion that all life is related and has descended from a common ancestor: the birds and the bananas, the fishes and the flowers -- all related. Darwin's general theory presumes the development of life from non-life and stresses a purely naturalistic (undirected) "descent with modification". That is, complex creatures evolve from more simplistic ancestors naturally over time. In a nutshell, as random genetic mutations occur within an organism's genetic code, the beneficial mutations are preserved because they aid survival -- a process known as "natural selection." These beneficial mutations are passed on to the next generation. Over time, beneficial mutations accumulate and the result is an entirely different organism (not just a variation of the original, but an entirely different creature).
Darwin's Theory of Evolution - Natural Selection
While Darwin's Theory of Evolution is a relatively young archetype, the evolutionary worldview itself is as old as antiquity. Ancient Greek philosophers such as Anaximander postulated the development of life from non-life and the evolutionary descent of man from animal. Charles Darwin simply brought something new to the old philosophy -- a plausible mechanism called "natural selection." Natural selection acts to preserve and accumulate minor advantageous genetic mutations. Suppose a member of a species developed a functional advantage (it grew wings and learned to fly). Its offspring would inherit that advantage and pass it on to their offspring. The inferior (disadvantaged) members of the same species would gradually die out, leaving only the superior (advantaged) members of the species. Natural selection is the preservation of a functional advantage that enables a species to compete better in the wild. Natural selection is the naturalistic equivalent to domestic breeding. Over the centuries, human breeders have produced dramatic changes in domestic animal populations by selecting individuals to breed. Breeders eliminate undesirable traits gradually over time. Similarly, natural selection eliminates inferior species gradually over time.
Darwin's Theory of Evolution - Slowly But Surely...
Darwin's Theory of Evolution is a slow gradual process. Darwin wrote, "…Natural selection acts only by taking advantage of slight successive variations; she can never take a great and sudden leap, but must advance by short and sure, though slow steps." [1] Thus, Darwin conceded that, "If it could be demonstrated that any complex organ existed, which could not possibly have been formed by numerous, successive, slight modifications, my theory would absolutely break down." [2] Such a complex organ would be known as an "irreducibly complex system". An irreducibly complex system is one composed of multiple parts, all of which are necessary for the system to function. If even one part is missing, the entire system will fail to function. Every individual part is integral. [3] Thus, such a system could not have evolved slowly, piece by piece. The common mousetrap is an everyday non-biological example of irreducible complexity. It is composed of five basic parts: a catch (to hold the bait), a powerful spring, a thin rod called "the hammer," a holding bar to secure the hammer in place, and a platform to mount the trap. If any one of these parts is missing, the mechanism will not work. Each individual part is integral. The mousetrap is irreducibly complex. [4]
Darwin's Theory of Evolution - A Theory In Crisis
Darwin's Theory of Evolution is a theory in crisis in light of the tremendous advances we've made in molecular biology, biochemistry and genetics over the past fifty years. We now know that there are in fact tens of thousands of irreducibly complex systems on the cellular level. Specified complexity pervades the microscopic biological world. Molecular biologist Michael Denton wrote, "Although the tiniest bacterial cells are incredibly small, weighing less than 10-12 grams, each is in effect a veritable micro-miniaturized factory containing thousands of exquisitely designed pieces of intricate molecular machinery, made up altogether of one hundred thousand million atoms, far more complicated than any machinery built by man and absolutely without parallel in the non-living world." [5]
And we don't need a microscope to observe irreducible complexity. The eye, the ear and the heart are all examples of irreducible complexity, though they were not recognized as such in Darwin's day. Nevertheless, Darwin confessed, "To suppose that the eye with all its inimitable contrivances for adjusting the focus to different distances, for admitting different amounts of light, and for the correction of spherical and chromatic aberration, could have been formed by natural selection, seems, I freely confess, absurd in the highest degree." [6]
Wednesday 3 August 2011
THE HUMAN BRAIN
This article is about features specific to the human brain. For basic information about brains, see Brain.
| Human brain | |
|---|---|
 | |
| Human brain and skull | |
 | |
| Cerebral lobes: the frontal lobe (pink), parietal lobe (green) and occipital lobe (blue) | |
| Latin | Cerebrum |
| Gray's | subject #184 736 |
| System | Central nervous system |
| Artery | Anterior communicating artery, middle cerebral artery |
| Vein | Cerebral veins, external veins, basal vein, terminal vein, choroid vein, cerebellar veins |
Brain evolution, from the earliest shrew-like mammals through primates to hominids, is marked by a steady increase in encephalization, or the ratio of brain to body size. Estimates vary for the number of neuronal and non-neuronal cells contained in the brain, ranging from 80 or 90 billion (~85 109) non-neuronal cells (glial cells) and an approximately equal number of (~86 109) neurons,[2] of which about 10 billion (1010) are cortical pyramidal cells, to over 120 billion neuronal cells, with an approximately equal number of non-neuronal cells.[3] These cells pass signals to each other via as many as 1000 trillion (1015, 1 quadrillion) synaptic connections.[4] Due to evolution, however, the modern human brain has been shrinking over the past 28,000 years.[5][6]
The brain monitors and regulates the body's actions and reactions. It continuously receives sensory information, and rapidly analyzes this data and then responds accordingly by controlling bodily actions and functions. The brainstem controls breathing, heart rate, and other autonomic processes that are independent of conscious brain functions. The neocortex is the center of higher-order thinking, learning, and memory. The cerebellum is responsible for the body's balance, posture, and the coordination of movement.
Despite being protected by the thick bones of the skull, suspended in cerebrospinal fluid, and isolated from the bloodstream by the blood-brain barrier, the human brain is susceptible to many types of damage and disease. The most common forms of physical damage are closed head injuries such as a blow to the head, a stroke
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